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CD47–SIRPα: - DiVA

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Many cancers are shown to be over-activated by the CD47 signal, also named as "Don't Eat Me" signal. It can evoke immune interaction with the cellular signal receptor protein alpha (SIRPα) to prevent programmed cell removal (PCR). CD47 is a high affinity receptor for thromobospondin-1, which plays a significant role in vascular development and angiogenesis. Thus, TRIL's hypotheses are exciting in the oncology and hematology A number of therapeutics that target the CD47/SIRPα axis are under preclinical and clinical investigation.

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However, the CD47 inhibitor 2021-4-1 · With the synergistic effect of fNP and anti-CD47 mAb on macrophage-mediated cancer cell removal in vivo, we hypothesized that the combination therapeutic of fNP, which elicits “eat me” signal by inducing CRT exposure, and anti-CD47 mAb, which blocks “don’t eat me” signal, may contributed to trigger anti-tumor immune response. CD47-SIRPα Pathway as a Target for Cancer Therapeutics By: Nicholas Garaffo Abstract According to the American Cancer Institute, in 2018, cancer had an estimated 1,735,350 new cases and 609,640 people will die in the United States alone. Like many deadly diseases, cancer has found ways to evade the immune system.

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2021-4-13 · Targeting the CD47/SIRPa axis works by using a drug to target CD47 on cancerous cells and thus enabling myeloid cells to attack and kill them via their corresponding receptor, SIRPa. CD47 is a cell surface receptor comprised of an extracellular IgV set domain, a 5 transmembrane domain, and a cytoplasmic tail that is alternatively spliced. Two ligands bind CD47: signal inhibitory receptor protein α (SIRPα) and thrombospondin-1 (TSP1). CD47 expression and/or activity has been implicated in a number of diseases and disorders. A number of therapeutics that target the CD47/SIRPα axis are under preclinical and clinical investigation.

2020-4-2 · CD47 is an immune checkpoint protein that downregulates both the innate and adaptive anti-tumor immune response via its counter receptor SIRPα.
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The CD47 Space Races to a Pivotal Trial. Wed, 23 Dec 2020. 79. - 079 - ASH 2020 Updates ($TRIL $TGTX company developing next-generation antibody therapies focused on the tumor microenvironment with lead programs targeting CD73, CD39, IL-27 and CD47.

We are committed to advancing antibodies with best-in-class potential. 2021-4-13 · Targeting the CD47/SIRPa axis works by using a drug to target CD47 on cancerous cells and thus enabling myeloid cells to attack and kill them via their corresponding receptor, SIRPa. CD47 is a cell surface receptor comprised of an extracellular IgV set domain, a 5 transmembrane domain, and a cytoplasmic tail that is alternatively spliced. Two ligands bind CD47: signal inhibitory receptor protein α (SIRPα) and thrombospondin-1 (TSP1). CD47 expression and/or activity has been implicated in a number of diseases and disorders. A number of therapeutics that target the CD47/SIRPα axis are under preclinical and clinical investigation.
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Abstract. Provided are anti-CD47 monoclonal antibodies 2 Mar 2020 CD47. 2020228. FortySeven FortySeven. 32%64 201912ASH TG Therapeutics . CD47. TG. TherapeuticsTG-1801 CD47/CD19.

FortySeven FortySeven. 32%64 201912ASH TG Therapeutics . CD47. TG. TherapeuticsTG-1801 CD47/CD19. CD47. 8 Jul 2019 “Our small molecule inhibitors represent a novel and innovative therapeutic approach to silence the critical CD47-SIRP alpha checkpoint signal 15 Jan 2021 M.D. Minden: clinical trial funding from Trillium Therapeutics Inc. D. Villa: skin involvement); prior anti-CD47 therapy (except prior TTI-621); 15 Jun 2019 At the 24th Congress of the European Hematology Association (EHA), David Sallman from the Moffitt Cancer Center, Tampa, US, discusses if 23 Dec 2020 CD47 is the latest immuno-oncology target and multiple companies are commercializing molecules in blood and solid tumors. Two exciting 1 Jul 2020 The company is a clinical stage firm developing CD47 checkpoint the global market for leukemia therapeutics was an estimated $12.3 billion 13 Jul 2020 Below is a brief overview video of CD47 proteins: the global market for leukemia therapeutics was an estimated $12.3 billion 2019 and is Agonist Immunotherapy Targets and Combination Therapies, 15-16 Nov 2018, and has demonstrated superior activity compared to CD47/CD40 antibody 3 Mar 2020 Blocking the CD47 "Don't Eat Me" Pathway Broad Portfolio of Potential Cancer Therapies.
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These therapeutics differ in their pharmacodynamic, pharmacokinetic and toxicological properties. 2020-12-07 · CD47 is a protective “don’t eat me” signal that blocks the ability of certain immune cells to destroy the tumor. By blocking this “don’t eat me” signal with decoy receptors, we aim to unmask tumor cells and make them visible to, and eradicated by, the immune system. BioSuperior™ Anti-CD47 Therapeutic Antibody (AVI-105) Our Company AbVision, Inc. (AVI) previously the Drug Discovery Group of BioVision Inc., is a privately held biopharmaceutical company headquartered in the San Francisco Bay Area. CD47 also known as integrin associated protein is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha.

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CD47 belongs to the immunoglobulin superfamily and partners with membrane integrins and also binds the ligands thrombospondin-1 and signal-regulatory protein alpha. CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis. CD47 Moreover, CD47 overexpression may blunt the therapeutic action of monoclonal antibodies, and therefore, CD47 blockade would enhance antibody efficacy . Additional strategies to block this axis involve engineered SIRPα monomers or exosomes with SIRPα that have a high affinity for CD47 and that would similarly lower the macrophage threshold for phagocytosis and, as a result, T cell activation Therapeutic blockade of the CD47-SIRPα pathway has led to robust pre-clinical efficacy in vivo with several therapeutics in clinical development. While the clinical data of such agents in myeloid malignancies has been limited, initial data with magrolimab, a first-in-class anti-CD47 antibody, has been shown to be well-tolerated with encouraging efficacy results when combined with azacitidine Trillium Therapeutics has two lead candidates that encourage immune cells known as “macrophages” to gobble up cancer cells by blocking a protein known as CD47.

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CD47 is expressed on all normal cells and targets SIRPα on the surface of myeloid cells. However, CD47 is found to be overexpressed on cancer cells. CD47/SIRPα, AN IMMUNE CHECKPOINT FORINNATE IMMUNE SYSTEM. Among cells of the myeloid lineage, macrophage has prominent potentials as the mediator of anti-cancer therapeutics based on its robust phagocytosis ability [8, 9]. CD47, known as an integrin-associated protein, was first identified as a transmembrane protein from red blood cells (RBC) .

The Company’s two clinical programs, TTI-621 and TTI-622, target CD47, a “do not eat me” signal that cancer cells frequently use to evade the immune system. For more information visit: www.trilliumtherapeutics.com A second anti-CD47 antibody (IMC-002) discovered from Sorrento’s G-MAB™ library was previously cleared by the FDA for clinical trial, and is currently in human testing by ImmuneOncia Therapeutics, LLC, a joint venture between Sorrento (35% ownership) and Yuhan Corporation. Trillium Therapeutics Inc. (“Trillium” or the “Company”) (NASDAQ/TSX:TRIL), a clinical stage immuno-oncology company developing innovative therapies for the treatment of cancer, announced Tallac Therapeutics™ is a privately held biopharmaceutical company harnessing the power of innate and adaptive immunity to fight cancer. Tallac’s pipeline of immunotherapy candidates are derived from the company’s novel Toll-like Receptor Agonist Antibody Conjugate (TRAAC) platform to deliver a potent Toll-like receptor (TLR9) agonist (T-CpG) for targeted immune activation via systemic William Casey Wilson, John Richards, Robyn J Puro, Gabriela Andrejeva, Ben J Capoccia, Mike J Donio, Ronald R Hiebsch, Prabir Chakraborty, Victoria Sung, Daniel S Pereira; AO-176, a Highly Differentiated Clinical Stage Anti-CD47 Antibody, Exerts Potent Anti-Tumor Activity in Preclinical Models of Multiple Myeloma As a Single Agent and in Combination with Approved Therapeutics.